The PRCD gene is highly expressed in the retina, while in other tissues expression is negligible. It encodes a protein of 54 amino acids (aa) in humans. Mutations in PRCD cause retinal degeneration in both humans and dogs. To further characterize the roles of PRCD in retinal function and in IRD we aim to identify PRCD-interacting proteins.
In addition, we produced a Prcd-knockout mouse and phenotypically characterized its retinal structure and function. This mouse model is a valuable tool for testing the function of PRCD and its protein-protein interactions in vivo.